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KMID : 1151820190130010133
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Journal of the Korean Society of Radiology
2019 Volume.13 No. 1 p.133 ~ p.140
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Triglycerides increase mRNA Expression of Pro-inflammatory Cytokines Via the iNOS in Jurkat T lymphocyte and U937 Monocyte Cell Lines
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Chang Jeong-Hyun
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Abstract
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Triglycerides (TG) are one of the triggers of chronic inflammatory lesions in the blood vessels. In the key factors in the development of inflammatory diseases, Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-)α and interleukin-1 beta (IL-1β) contribute to the development of inflammatory lesions by recruiting other immune cells in the inflamed area or causing cell necrotic death. In this study, I investigated the effect of Jurkat T lymphocytes and U937 monocytes involved in vascular inflammation development on the expression of TNF-α and IL-1β on exposure to TGs. In Jurkat cells, mRNA expression of TNF-α is increased by exposure to TGs. However, the expression levels of TNF-α and IL-1β were increased by TGs in U937 cells. To investigate whether inducible nitric oxide synthase (iNOS) is involved in the increase of expression of TNF-α and IL-1β by TGs, treatment of W1400 (an iNOS inhibitor) resulted in recovery of expression level both TNF- α and IL-1β. Based on the present study, it was confirmed that the expression of TNF-α and IL-1β in monocytes and T lymphocytes. This increased cytokines contribute to development of vascular inflammatory lesions. In addition, iNOS is involved in the increase of TNF-α and IL-1β expression by TGs.
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KEYWORD
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triglyceride (TG), TNF-α, IL-1β, iNOS
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